Transfer of benzo(a)pyrene into mouse embryos and fetuses

Arch Toxicol. 1988;62(2-3):236-9. doi: 10.1007/BF00570149.

Abstract

The distribution of radioactive material within maternal and embryonic/fetal mouse tissue was studied over a period of 2 days following a single dose of 14C-benzo(a)pyrene (B(a)P) orally on days 11, 12, 13 or 18 of pregnancy. B(a)P poorly penetrated into the embryo/fetus, and 14C-radioactivity was found in embryonic tissues at concentrations one to two orders of magnitude lower than in maternal organs. If the compound was administered for 3 consecutive days at the same dose the expected cumulation was compensated for by an accelerated elimination of the substance, which is probably due to enzyme induction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzo(a)pyrene / pharmacokinetics*
  • Embryo, Mammalian / metabolism*
  • Female
  • Fetus / metabolism*
  • Mice
  • Pregnancy
  • Tissue Distribution

Substances

  • Benzo(a)pyrene