Cell Biology: Tight Junctions as Biomolecular Condensates

Curr Biol. 2020 Jan 20;30(2):R83-R86. doi: 10.1016/j.cub.2019.11.060.

Abstract

Two recent studies report that ZO proteins, the main scaffolding proteins of tight junctions, undergo liquid phase separation. This new concept provides understanding at the mechanistic level of how tight junctions are formed and how they participate in mechanochemical signaling in early development.

Publication types

  • Comment

MeSH terms

  • Phosphoproteins*
  • Signal Transduction
  • Tight Junctions*
  • Zonula Occludens Proteins
  • Zonula Occludens-1 Protein

Substances

  • Phosphoproteins
  • Zonula Occludens Proteins
  • Zonula Occludens-1 Protein