Amino Acid Sensing: Architecture of mTORC1 on the Lysosome Surface

Curr Biol. 2020 Jan 20;30(2):R89-R91. doi: 10.1016/j.cub.2019.11.087.

Abstract

Amino acid signaling through the Rag GTPases promotes mTORC1 lysosomal localization and subsequent activation. Two new cryo-EM structures examine the architecture of the Rag GTPase heterodimers complexed with mTORC1.

Publication types

  • Comment

MeSH terms

  • Amino Acids
  • Lysosomes
  • Mechanistic Target of Rapamycin Complex 1
  • Monomeric GTP-Binding Proteins*
  • Signal Transduction

Substances

  • Amino Acids
  • Mechanistic Target of Rapamycin Complex 1
  • Monomeric GTP-Binding Proteins