Acute nonlymphocytic leukemia following short-term, intermittent, intravenous cyclophosphamide treatment of lupus nephritis

Arthritis Rheum. 1988 Dec;31(12):1552-4. doi: 10.1002/art.1780311212.

Abstract

Intermittent intravenous cyclophosphamide therapy has been shown to be effective in the management of lupus nephritis. There have been no reports of malignancies associated with such treatment regimens. We describe a patient who developed acute nonlymphocytic leukemia after receiving a total dose of 4 gm of cyclophosphamide over a 1-year period.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Cyclophosphamide / administration & dosage
  • Cyclophosphamide / adverse effects*
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Female
  • Humans
  • Injections, Intravenous
  • Leukemia, Myeloid, Acute / chemically induced*
  • Lupus Nephritis / drug therapy*
  • Prednisone / administration & dosage
  • Risk Factors

Substances

  • Cyclophosphamide
  • Prednisone