HLA-DR antigens and anticardiolipin antibodies in northern Italian systemic lupus erythematosus patients

Arthritis Rheum. 1988 Dec;31(12):1568-70. doi: 10.1002/art.1780311216.


Eighty systemic lupus erythematosus (SLE) patients attending 3 clinical centers were evaluated immunologically and immunogenetically. No HLA class II antigens were found to be significantly associated with SLE in these patients. A highly significant (P = 6.17 x 10(-7) association was observed between anticardiolipin antibodies and DR7. A lesser association (P less than 0.025) was also observed between DR2 and/or DR3 and anti-Ro (SS-A) antibodies. No relationship was found between any DR antigen and anti-Sm/RNP, anti-double-stranded DNA, or anti-La (SS-B) antibodies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Autoantibodies / analysis*
  • Cardiolipins / immunology*
  • Child
  • Cohort Studies
  • Female
  • HLA Antigens / analysis
  • HLA-DR Antigens / analysis*
  • Humans
  • Italy
  • Lupus Erythematosus, Systemic / immunology*
  • Male
  • Middle Aged


  • Autoantibodies
  • Cardiolipins
  • HLA Antigens
  • HLA-DR Antigens