Relationship between nerve fiber layer defect and the presence of epiretinal membrane in a Japanese population: The JPHC-NEXT Eye Study

Sci Rep. 2020 Jan 21;10(1):779. doi: 10.1038/s41598-019-57260-7.


The study subjects were residents of Chikusei city, Japan, aged 40 years or older who attended annual health check-up programs and participated in the JPHC-NEXT Eye Study which performed non-mydriatic fundus photography of both eyes. The relationship of glaucomatous fundus changes such as optic disc cupping (cup to disc ratio ≥ 0.7) and retinal nerve fiber layer defect (NFLD) with the presence of epiretinal membrane (ERM) were examined cross-sectionally. A total of 1990 persons gave consent to participate in this study in 2013. The overall prevalence of ERM was 12.9%. Of these, 1755 had fundus photographs of sufficient quality and no history of intraocular surgery (mean age: 62.3 ± 10.0 years). After adjusting for age, sex and refractive error, NFLD was positively associated with the presence of ERM (odds ratio [OR]: 2.48; 95% confidence interval [CI]: 1.24, 4.96; P = 0.010), but optic disc cupping was not (OR: 1.33; CI: 0.71, 2.48; P = 0.37). The results did not necessarily suggest an association between glaucoma and ERM, but indicated an association between NFLD and ERM.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cross-Sectional Studies
  • Epiretinal Membrane / diagnostic imaging
  • Epiretinal Membrane / epidemiology*
  • Epiretinal Membrane / pathology
  • Female
  • Glaucoma / diagnostic imaging
  • Glaucoma / epidemiology*
  • Glaucoma / pathology
  • Humans
  • Japan / epidemiology
  • Male
  • Middle Aged
  • Nerve Fibers / pathology*
  • Optic Disk / diagnostic imaging
  • Prevalence