[Contact allergy due to insulin pumps and glucose sensor systems]

Hautarzt. 2020 Mar;71(3):205-210. doi: 10.1007/s00105-019-04533-x.
[Article in German]


The design and development of insulin pumps and various glucose sensor systems has an enormous impact on life quality of diabetic patients. Surveillance and therapy of diabetes has improved due to the new diabetic devices, which are affixed to the patients' skin for several days. Since their introduction, irritant and allergic contact dermatitis have been frequently reported. Patients often acquire contact sensitization to isobornyl acrylate, N,N-dimethylacrylamide or formerly to 2‑ethyl-cyanoacrylate. These contact allergens were found in the patch, in the glue to affix the box on the patch or in the casing of the system itself. Development of contact allergy to substances of these systems may result in the need to abandon modern diabetic devices.

Keywords: Contact hypersensitivity; Glucose sensors; Insulin infusion systems; Insulin-dependent diabetes; Isobornyl acrylate.

Publication types

  • Review

MeSH terms

  • Acetates
  • Adhesives / adverse effects*
  • Allergens / adverse effects*
  • Blood Glucose Self-Monitoring / adverse effects*
  • Blood Glucose Self-Monitoring / instrumentation
  • Bridged Bicyclo Compounds
  • Dermatitis, Allergic Contact / etiology*
  • Dermatitis, Allergic Contact / prevention & control
  • Diabetes Mellitus
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / drug therapy
  • Foreign-Body Reaction / etiology
  • Glucose
  • Humans
  • Inflammation / etiology*
  • Insulin Infusion Systems / adverse effects*
  • Insulins / administration & dosage
  • Insulins / therapeutic use
  • Patch Tests / methods*


  • Acetates
  • Adhesives
  • Allergens
  • Bridged Bicyclo Compounds
  • Insulins
  • 2-ethylhexyl acetate
  • isobornyl alpha-(methylthio)acetate
  • Glucose