Bone morphogenetic protein 7 alleviates paraquat-induced pulmonary fibrosis via TGF-β1/Erk1/2 pathway

Yongsheng Wang; Shuang Ren; Lin Liu; Rong Yao; Xiaojuan Ma; Lei Chen

Bone morphogenetic protein 7 alleviates paraquat-induced pulmonary fibrosis via TGF-β1/Erk1/2 pathway

Int J Clin Exp Pathol. 2017 Aug 1;10(8):8503-8509. eCollection 2017.

Authors

Yongsheng Wang¹, Shuang Ren², Lin Liu³, Rong Yao⁴, Xiaojuan Ma¹, Lei Chen²

Affiliations

¹ Department of Respiratory Medicine, Chengdu First People's Hospital Chengdu, Sichuan, China.
² Department of Respiratory and Critical Care Medicine, West China Hospital, West China School of Medicine, Sichuan University Chengdu, Sichuan, China.
³ Department of Respiratory Medicine, 363 Hospital Chengdu, Sichuan, China.
⁴ Department of Emergency Medicine, West China Hospital, West China School of Medicine, Sichuan University Chengdu, Sichuan, China.

PMID: 31966703
PMCID: PMC6965432

Abstract

Bone morphogenetic protein 7 (BMP-7) recently demonstrates an anti-fibrotic effect. To evaluate the role of BMP-7 in paraquat (PQ)-induced pulmonary fibrosis, PQ-exposed mice and lung fibroblasts (MRC-5) were treated with BMP-7. Our results showed that BMP-7 treatment could significantly reduce PQ-induced pulmonary fibrosis, accompanied by downregulation of transforming growth factor (TGF)-β1 and collagen I deposition in mouse lungs. Moreover, PQ-induced inviability, apoptosis, high level of collagen I, as well as phosphorylation of Erk1/2, in MRC-5 cells were significantly inhibited by BMP-7 treatment. These findings indicate BMP-7 alleviates PQ-induced pulmonary fibrosis partly via TGF-β1/Erk1/2 pathway, suggesting a promising therapeutic means for PQ-induced fibrotic lung injury.

Keywords: Bone morphogenetic protein; mitogen activated protein kinase; paraquat; pulmonary fibrosis; transforming growth factor-β1.