Humoral Factors From Musculoskeletal Polytrauma Patients Impair Antibacterial Responses Of Neutrophils In vitro

Aikaterini Stylianaki; Barbara Stanic; Mario Morgenstern; Geoff R Richards; Fintan T Moriarty; Keith Thompson

doi:10.7150/jbji.35424

Humoral Factors From Musculoskeletal Polytrauma Patients Impair Antibacterial Responses Of Neutrophils In vitro

J Bone Jt Infect. 2019 Nov 7;4(6):280-284. doi: 10.7150/jbji.35424. eCollection 2019.

Authors

Aikaterini Stylianaki¹, Barbara Stanic¹, Mario Morgenstern², Geoff R Richards¹, Fintan T Moriarty¹, Keith Thompson¹

Affiliations

¹ AO Research Institute Davos, Davos, Switzerland.
² Department of Orthopaedic and Trauma Surgery, University Hospital Basel, Switzerland.

Abstract

Polytrauma is associated with increased risk of sepsis, but the risk for implant infection is less clear. Neutrophil antibacterial responses are significantly reduced in polytrauma patients (n= 9, ISS≥15) for at least 5 days compared to healthy controls. Reduced neutrophil activity could influence implant infection in addition to sepsis.

Keywords: antibacterial activity; neutrophil; polytrauma.