P-selectin-deficient mice to study pathophysiology of sickle cell disease

Blood Adv. 2020 Jan 28;4(2):266-273. doi: 10.1182/bloodadvances.2019000603.


  1. P-selectin–deficient SCD mice are protected from lung vaso-occlusion.

  2. P-selectin–deficient SCD mice will be useful in assessing the benefits of anti–P-selectin therapy in diverse complications of SCD.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anemia, Sickle Cell / physiopathology*
  • Animals
  • Humans
  • Male
  • Mice
  • P-Selectin / deficiency*
  • Rats


  • P-Selectin