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. 2020 Jan 22;5(1):e00972-19.
doi: 10.1128/mSphere.00972-19.

Candida Auris Biofilm Colonization on Skin Niche Conditions

Free PMC article

Candida Auris Biofilm Colonization on Skin Niche Conditions

Priya Uppuluri. mSphere. .
Free PMC article


Candida auris, an emerging multidrug-resistant yeast, has recently been associated with outbreaks of invasive infections in health care facilities worldwide. Its success as a nosocomial pathogen lies in its capability to sustain for prolonged periods in the intensive care unit (ICU), adeptly colonize skin, and spread among patients. Little is known of the mechanism behind the predilection of C. auris for skin or the extent of its resilience on it. Now, M. V. Horton, C. J. Johnson, J. F. Kernien, T. D. Patel, et al. (mSphere 5:e00910-19, 2020, demonstrate that in synthetic sweat medium designed to mimic axillary skin conditions, C. auris can grow into multilayers of cells called biofilms that can resist desiccation. C. auris' propensity to form biofilms was further elaborated using a novel ex vivo porcine skin model of skin colonization. These studies provide early evidence that C. auris biofilm cells persisting on skin could serve as source of continuing outbreaks in health care facilities. Interventions blocking C. auris biofilm growth on skin will help control the spread of this pathogen.

Keywords: Candida auris; biofilm; fungi; nosocomial; porcine; skin; sweat.

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    1. Lockhart SR, Etienne KA, Vallabhaneni S, Farooqi J, Chowdhary A, Govender NP, Colombo AL, Calvo B, Cuomo CA, Desjardins CA, Berkow EL, Castanheira M, Magobo RE, Jabeen K, Asghar RJ, Meis JF, Jackson B, Chiller T, Litvintseva AP. 2017. Simultaneous emergence of multidrug-resistant Candida auris on 3 continents confirmed by whole-genome sequencing and epidemiological analyses. Clin Infect Dis 64:134–140. doi:10.1093/cid/ciw691. - DOI - PMC - PubMed
    1. Nett JE. 2019. Candida auris: an emerging pathogen “incognito”? PLoS Pathog 15:e1007638. doi:10.1371/journal.ppat.1007638. - DOI - PMC - PubMed
    1. Satoh K, Makimura K, Hasumi Y, Nishiyama Y, Uchida K, Yamaguchi H. 2009. Candida auris sp. nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital. Microbiol Immunol 53:41–44. doi:10.1111/j.1348-0421.2008.00083.x. - DOI - PubMed
    1. Lee WG, Shin JH, Uh Y, Kang MG, Kim SH, Park KH, Jang HC. 2011. First three reported cases of nosocomial fungemia caused by Candida auris. J Clin Microbiol 49:3139–3142. doi:10.1128/JCM.00319-11. - DOI - PMC - PubMed
    1. Adams E, Quinn M, Tsay S, Poirot E, Chaturvedi S, Southwick K, Greenko J, Fernandez R, Kallen A, Vallabhaneni S, Haley V, Hutton B, Blog D, Lutterloh E, Zucker H., Candida auris Investigation Workgroup. 2018. Candida auris in healthcare facilities, New York, USA, 2013–2017. Emerg Infect Dis 24:1816–1824. doi:10.3201/eid2410.180649. - DOI - PMC - PubMed