Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells

Nature. 2020 Jan;577(7792):676-681. doi: 10.1038/s41586-020-1935-3. Epub 2020 Jan 22.


Empirical and anecdotal evidence has associated stress with accelerated hair greying (formation of unpigmented hairs)1,2, but so far there has been little scientific validation of this link. Here we report that, in mice, acute stress leads to hair greying through the fast depletion of melanocyte stem cells. Using a combination of adrenalectomy, denervation, chemogenetics3,4, cell ablation and knockout of the adrenergic receptor specifically in melanocyte stem cells, we find that the stress-induced loss of melanocyte stem cells is independent of immune attack or adrenal stress hormones. Instead, hair greying results from activation of the sympathetic nerves that innervate the melanocyte stem-cell niche. Under conditions of stress, the activation of these sympathetic nerves leads to burst release of the neurotransmitter noradrenaline (also known as norepinephrine). This causes quiescent melanocyte stem cells to proliferate rapidly, and is followed by their differentiation, migration and permanent depletion from the niche. Transient suppression of the proliferation of melanocyte stem cells prevents stress-induced hair greying. Our study demonstrates that neuronal activity that is induced by acute stress can drive a rapid and permanent loss of somatic stem cells, and illustrates an example in which the maintenance of somatic stem cells is directly influenced by the overall physiological state of the organism.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adrenal Glands / metabolism
  • Adrenalectomy
  • Animals
  • Autonomic Pathways / pathology
  • Autonomic Pathways / physiopathology*
  • Cell Proliferation
  • Cells, Cultured
  • Denervation
  • Female
  • Hair Color / physiology*
  • Humans
  • Male
  • Melanocytes / cytology
  • Melanocytes / metabolism
  • Melanocytes / pathology*
  • Mice
  • Norepinephrine / metabolism
  • Psychological Trauma / pathology
  • Psychological Trauma / physiopathology
  • Receptors, Adrenergic, beta-2 / deficiency
  • Receptors, Adrenergic, beta-2 / metabolism
  • Stem Cell Niche / physiology*
  • Stem Cells / cytology
  • Stem Cells / metabolism
  • Stem Cells / pathology*
  • Stress, Psychological / pathology
  • Stress, Psychological / physiopathology*
  • Sympathetic Nervous System / pathology
  • Sympathetic Nervous System / physiopathology*


  • ADRB2 protein, human
  • Receptors, Adrenergic, beta-2
  • Norepinephrine