Caudate Volume Mediates the Interaction between Total Sleep Time and Executive Function after Acute Exercise in Healthy Older Adults

Junyeon Won; Alfonso J Alfini; Lauren R Weiss; Casandra C Nyhuis; Adam P Spira; Daniel D Callow; J Carson Smith

doi:10.3233/BPL-190087

Caudate Volume Mediates the Interaction between Total Sleep Time and Executive Function after Acute Exercise in Healthy Older Adults

Brain Plast. 2019 Dec 26;5(1):69-82. doi: 10.3233/BPL-190087.

Authors

Junyeon Won¹, Alfonso J Alfini², Lauren R Weiss^{1

3}, Casandra C Nyhuis², Adam P Spira^{2

4

5}, Daniel D Callow^{1

3}, J Carson Smith^{1

3}

Affiliations

¹ Department of Kinesiology, University of Maryland, College Park, MD, USA.
² Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
³ Program in Neuroscience and Cognitive Science, University of Maryland, College Park, MD, USA.
⁴ Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
⁵ Center on Aging and Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Abstract

Although both exercise and sleep are significant lifestyle factors in cognitive aging, the interaction of these two factors with respect to cognition remains to be determined. Also, little is known regarding the role of the basal ganglia (BG) in cognitive aging despite its involvement in both sleep and executive function. The primary objective of this study was to investigate the interaction between sleep and acute exercise on executive function performance, and secondarily, to assess if BG volume mediates this interaction. Thirty healthy older adults (65.8±7.3 years) completed 30 minutes of seated rest or moderate-intensity cycling exercise on different days. Structural MRI was used to assess the volumes of BG components including caudate, putamen, and globus pallidus shortly after the experimental conditions. Approximately 90 minutes after each condition, the Stroop task was administered to measure executive function. To examine sleep, participants wore a wrist actigraph for 8.0±3.6 days prior to the first experimental session. Results revealed that while longer total sleep time (TST) was associated with shorter Stroop response time (RT), shorter TST was associated with longer RT after exercise, compared to rest, for both congruent (p = 0.029) and incongruent (p = 0.022) trials. Longer TST was correlated with greater caudate volume, and greater caudate volume was associated with exercise-related improvement in Stroop incongruent RT. Ultimately, we found that the association between longer sleep duration and faster processing speed after acute exercise was mediated by greater caudate volume. These findings suggest that TST is an important factor for acute exercise-induced cognitive improvements in older adults, and that our study is a first step in understanding the interactive effects of these important lifestyle factors in cognitive aging that might simultaneously be addressed to promote healthy cognitive aging. Future studies should examine the interactive effects of sleep and chronic exercise on cognitive function, and whether BG volume might also mediate this interaction.

Keywords: Sleep; acute exercise; basal ganglia; caudate; executive function; mediation; older adults; the Stroop task.

Abstract

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