Influence of combined oral contraceptives on polycystic ovarian morphology-related parameters in Korean women with polycystic ovary syndrome

Obstet Gynecol Sci. 2020 Jan;63(1):80-86. doi: 10.5468/ogs.2020.63.1.80. Epub 2019 Dec 20.

Abstract

Objective: This study aimed to assess the effect of combined oral contraceptives (COCs) on polycystic ovarian morphology (PCOM) and serum anti-Müllerian hormone (AMH) levels in Korean women with polycystic ovary syndrome (PCOS).

Methods: This university hospital study enrolled 36 Korean women who were newly diagnosed with PCOS based on the Rotterdam criteria and were treated with COCs for at least 1 year. We retrospectively evaluated the ovarian volume and number of antral follicles using ultrasonography and assessed serum AMH levels at baseline and after 1 year of COC treatment.

Results: Significant decreases in ovarian volume and antral follicle count were observed after 1 year of COC treatment. Compared to baseline, serum AMH levels were significantly decreased after 1 year.

Conclusion: COC treatment significantly affects ultrasound-assessed PCOM and serum AMH levels of patients with PCOS.

Keywords: Anti-Müllerian hormone; Combined oral contraceptives; Polycystic ovarian morphology; Polycystic ovary syndrome.