Abstract
Withdrawal from long-term treatment with benzodiazepines was followed in three patients by a severe delusional depression. The delusional depression may be related to the neurotransmitter changes accompanying benzodiazepine withdrawal. Caution should be exercised in long-term use of benzodiazepines in susceptible individuals.
MeSH terms
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Adult
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Anxiety Disorders / drug therapy*
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Delusions / chemically induced*
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Delusions / psychology
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Depressive Disorder / chemically induced*
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Depressive Disorder / psychology
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Diazepam / adverse effects*
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Diazepam / therapeutic use
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Female
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Humans
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Lorazepam / adverse effects*
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Lorazepam / therapeutic use
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Male
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Middle Aged
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Substance Withdrawal Syndrome / psychology*