Delusional depression following benzodiazepine withdrawal

Can J Psychiatry. 1988 Oct;33(7):626-7. doi: 10.1177/070674378803300709.

Abstract

Withdrawal from long-term treatment with benzodiazepines was followed in three patients by a severe delusional depression. The delusional depression may be related to the neurotransmitter changes accompanying benzodiazepine withdrawal. Caution should be exercised in long-term use of benzodiazepines in susceptible individuals.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anxiety Disorders / drug therapy*
  • Delusions / chemically induced*
  • Delusions / psychology
  • Depressive Disorder / chemically induced*
  • Depressive Disorder / psychology
  • Diazepam / adverse effects*
  • Diazepam / therapeutic use
  • Female
  • Humans
  • Lorazepam / adverse effects*
  • Lorazepam / therapeutic use
  • Male
  • Middle Aged
  • Substance Withdrawal Syndrome / psychology*

Substances

  • Lorazepam
  • Diazepam