The emerging role of dipeptidyl-peptidase-4 as a therapeutic target in lung disease

Expert Opin Ther Targets. 2020 Feb;24(2):147-153. doi: 10.1080/14728222.2020.1721468. Epub 2020 Jan 31.


Introduction: Dipeptidyl-peptidase-4 (DPP-4) is a surface bound ectopeptidase that is commonly known as CD26 or adenosine deaminase binding protein. DPP-4 is membrane anchored but it can be cleaved by numerous proteases including matrix-metalloproteinases (MMPs). DPP-4 is expressed by endothelial and epithelial cells, the kidney, intestine and cells of the immune system; it has a broad spectrum of biological functions in immune regulation, cancer biology and glucose metabolism.Areas covered: This article sheds light on the functions of DPP-4, the molecular mechanisms that govern its expression, it's role in the pathogenesis of common respiratory illnesses and potential as a therapeutic target.Expert opinion: DPP-4 has a deleterious role in respiratory disease. Its biological functions, key molecular pathways, interactions and associations are slowly being elucidated. Progressing our knowledge of the role of this multi-faceted molecule may yield vital and novel therapies for respiratory diseases such as lung cancer, asthma, and chronic obstructive pulmonary disease (COPD).

Keywords: Asthma; chronic obstructive pulmonary disease (COPD); cluster of differentiation 26 (CD26); dipeptidyl-peptidase-4 (DPP-4).

Publication types

  • Review

MeSH terms

  • Animals
  • Dipeptidyl Peptidase 4 / genetics
  • Dipeptidyl Peptidase 4 / metabolism*
  • Gene Expression Regulation
  • Humans
  • Lung Diseases / physiopathology
  • Lung Diseases / therapy*
  • Molecular Targeted Therapy*


  • DPP4 protein, human
  • Dipeptidyl Peptidase 4