Psoriasis and Treatment: Past, Present and Future Aspects

Acta Derm Venereol. 2020 Jan 30;100(3):adv00032. doi: 10.2340/00015555-3386.


The management of psoriasis has evolved considerably over the past 100 years. This has occurred in parallel with our understanding of the pathogenesis of this common, complex and enigmatic disease. It should be celebrated as an outstanding example of successful translational research. With precise targeting of immune pathways for the treatment of psoriasis with new biologics and small molecules has come the realisation that the most effective approach to patient management is a holistic one which encompasses the biopsychosocial nature of the disease. This involves a stratified medicine approach to identifying the best drug for an individual allied to patient education, screening for comorbidity, and regular review as both the clinical presentation and the patient's needs will change over time. Al-though there is not yet a cure for psoriasis - the whole person, systems approach to patient management, that is in part dependent on early intervention, should help to ensure an optimal outcome.

Keywords: psoriasis; treatment.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Biological Products / therapeutic use*
  • Dermatologic Agents / therapeutic use*
  • Disease Management
  • Drug Development
  • Furocoumarins / therapeutic use
  • History, 20th Century
  • History, 21st Century
  • Holistic Health
  • Humans
  • Life Style
  • Molecular Targeted Therapy
  • PUVA Therapy
  • Patient Education as Topic
  • Psoriasis / drug therapy
  • Psoriasis / history*


  • Adrenal Cortex Hormones
  • Biological Products
  • Dermatologic Agents
  • Furocoumarins