Neurological manifestations of the hypereosinophilic syndrome (HES)

Clin Neurol Neurosurg. 1988;90(3):269-73. doi: 10.1016/0303-8467(88)90036-4.


The hypereosinophilic syndrome (HES) is a rare disease, characterized by a long lasting hypereosinophilia of the blood and the marrow and by the presence of varying internal symptoms and frequent neurological signs. These latter can be as well central: encephalomalacy, organic psycho-syndrome, as peripheral: polyneuropathy or mononeuropathia multiplex, autonomic neuropathy and in rare cases a polymyositis. The disease clinically resembles very to periarteriitis nodosa (PAN). However, the prognosis of HES is far better, especially when early recognized and adequately treated.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Aged
  • Brain Diseases / complications*
  • Brain Diseases / diagnosis
  • Brain Diseases / drug therapy
  • Eosinophilia / complications*
  • Eosinophilia / diagnosis
  • Eosinophilia / drug therapy
  • Female
  • Humans
  • Syndrome


  • Adrenal Cortex Hormones