Antibodies to brain cell-surface proteins have recently been identified in patients whose symptoms cross the boundary between neurology and psychiatry and are associated with syndromes that are responsive to treatment with immunosuppression-based treatments. This has led to an expansion in the field of autoimmune encephalitis. The common syndromes, with particular relevance to psychiatry, are discussed, in particular the N-methyl-d-aspartate receptor antibody encephalitis syndrome, which is most often associated with a psychosis and cognitive prodrome resembling acute or first-episode psychosis. The recognition, clinical diagnosis and associations, and evidence for disease mechanisms are discussed in this brief review.
Copyright © by the American Psychiatric Association.
Neuroimmunological antibody-mediated encephalitis and implications for diagnosis and therapy in neuropsychiatry.Acta Neuropsychiatr. 2019 Dec 3:1-9. doi: 10.1017/neu.2019.50. Online ahead of print. Acta Neuropsychiatr. 2019. PMID: 31791436
Early recognition of anti-N-methyl D-aspartate (NMDA) receptor encephalitis presenting as acute psychosis.Australas Psychiatry. 2013 Dec;21(6):596-9. doi: 10.1177/1039856213506502. Epub 2013 Oct 9. Australas Psychiatry. 2013. PMID: 24108083
Antibodies to the N-methyl-D-aspartate receptor and other synaptic proteins in psychosis.Biol Psychiatry. 2014 Feb 15;75(4):284-91. doi: 10.1016/j.biopsych.2013.07.018. Epub 2013 Aug 26. Biol Psychiatry. 2014. PMID: 23988024 Review.
Anti-N-Methyl-D-Aspartate Encephalitis as Paraneoplastic Manifestation of Germ-Cells Tumours: A Cases Report and Literature Review.Case Reports Immunol. 2019 Mar 10;2019:4762937. doi: 10.1155/2019/4762937. eCollection 2019. Case Reports Immunol. 2019. PMID: 30963010 Free PMC article.
Anti N-methyl-D-aspartate receptor encephalitis: a game-changer?Expert Rev Neurother. 2016 Jul;16(7):849-59. doi: 10.1080/14737175.2016.1184088. Epub 2016 May 17. Expert Rev Neurother. 2016. PMID: 27123777 Review.
Cited by 1 article
Clinical Neuropsychiatry.Focus (Am Psychiatr Publ). 2016 Oct;14(4):409. doi: 10.1176/appi.focus.20160024. Epub 2016 Oct 7. Focus (Am Psychiatr Publ). 2016. PMID: 31975820 Free PMC article. No abstract available.