Growth enhancement of transgenic mice expressing human insulin-like growth factor I

Endocrinology. 1988 Dec;123(6):2827-33. doi: 10.1210/endo-123-6-2827.


A line of transgenic mice carrying a chimeric gene composed of human insulin-like growth factor I (IGF-I) coding sequences fused to the mouse metallothionein I promoter was generated to study the effects of chronically elevated exposure to IGF-I. Mice in this line overexpress IGF-I in most tissues studied and have circulating IGF-I levels 1.5 times the normal value. This results in a growth response manifested by a 1.3-fold increase in weight as a result of selective organomegaly without an apparent increase in skeletal growth. In addition, expression of the endogenous GH and IGF-I genes is inhibited. These results are consistent with IGF-I playing an important role in the control of somatic growth.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Bone Development
  • DNA, Recombinant
  • Female
  • Gene Expression Regulation
  • Growth Hormone / genetics
  • Growth*
  • Humans
  • Insulin-Like Growth Factor I / genetics*
  • Insulin-Like Growth Factor I / physiology
  • Male
  • Metallothionein / genetics
  • Mice
  • Mice, Transgenic
  • Nucleic Acid Hybridization
  • Oligonucleotide Probes
  • Organ Size
  • Promoter Regions, Genetic
  • RNA, Messenger / analysis
  • RNA, Messenger / genetics
  • Somatomedins / genetics*
  • Transcription, Genetic
  • Weight Gain


  • DNA, Recombinant
  • Oligonucleotide Probes
  • RNA, Messenger
  • Somatomedins
  • Insulin-Like Growth Factor I
  • Growth Hormone
  • Metallothionein