Correlation of Visual Quality of Life With Clinical and Visual Status in Friedreich Ataxia

J Neuroophthalmol. 2020 Jun;40(2):213-217. doi: 10.1097/WNO.0000000000000878.


Background: The primary objective was to determine the association of patient-reported vision-specific quality of life to disease status and visual function in patients with Friedreich's ataxia (FRDA).

Methods: Patients with FRDA were assessed with the 25-Item National Eye Institute Visual Functioning Questionnaire (NEI-VFQ-25) along with measures of disease status (ataxia stage) and visual function (low- and high-contrast letter acuity scores). The relations of NEI-VFQ-25 scores to those for disease status and visual function were examined.

Results: Scores for the NEI-VFQ-25 were lower in patients with FRDA (n = 99) compared with published disease-free controls, particularly reduced in a subgroup of FRDA patients with features of early onset, older age, and abnormal visual function.

Conclusions: The NEI-VFQ-25 captures the subjective component of visual function in patients with FRDA.