Long-lived lines of Caenorhabditis elegans can be used to establish predictive biomarkers of aging

Exp Gerontol. 1988;23(4-5):281-95. doi: 10.1016/0531-5565(88)90031-9.


Long-lived recombinant inbred lines, some of which have mean and maximum life spans up to 70% longer than wild type, were used in these analyses. Longer life results from a slower exponential rate of increase in mortality. General motor activity decreases with chronological age in all genotypes; this decay in general motor activity is a biomarker of aging in that it is a predictor of maximum life span. The aging process has also been dissected into component processes. The length of development and the length of reproduction are unrelated to increased life span; lengthened life is due entirely to an increase in post-reproductive life span. Development, reproduction, and life span are each under independent genetic control. General motor activity and life span share at least one common rate-determining genetic component.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aging / physiology*
  • Animals
  • Biomarkers*
  • Caenorhabditis / physiology*
  • Inbreeding
  • Life Expectancy
  • Models, Biological*
  • Motor Activity
  • Reproduction


  • Biomarkers