Association Between Atg5-independent Alternative Autophagy and Neurodegenerative Diseases

J Mol Biol. 2020 Apr 3;432(8):2622-2632. doi: 10.1016/j.jmb.2020.01.016. Epub 2020 Jan 21.

Abstract

Autophagy is a cellular process that degrades intracellular components, including misfolded proteins and damaged organelles. Many neurodegenerative diseases are considered to progress via the accumulation of misfolded proteins and damaged organelles; therefore, autophagy functions in regulating disease severity. There are at least two types of autophagy (canonical autophagy and alternative autophagy), and canonical autophagy has been applied to therapeutic strategies against various types of neurodegenerative diseases. In contrast, the role of alternative autophagy has not yet been clarified, but it is speculated to be involved in the pathogenesis of various neurodegenerative diseases, including Alzheimer's disease.

Keywords: Alzheimer’s disease; GOMED; alternative autophagy; canonical autophagy; neurodegenerative disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autophagy*
  • Autophagy-Related Protein 5 / metabolism*
  • Humans
  • Neurodegenerative Diseases / metabolism*
  • Neurodegenerative Diseases / pathology*

Substances

  • Autophagy-Related Protein 5