Long non-coding RNA TP73-AS1 in cancers

Clin Chim Acta. 2020 Apr:503:151-156. doi: 10.1016/j.cca.2019.12.025. Epub 2020 Jan 21.

Abstract

More and more evidence indicates that long non-coding RNAs (lncRNAs), as a kind of non-coding endogenous single-stranded RNA, play an essential role as oncogenes or tumour suppressors in the occurrence and development of human cancers. The tumour protein P73 antisense RNA 1 (TP73-AS1) was initially found to be down-regulated in oligodendroglioma and may act as a non-protein-encoding RNA. Since its discovery, TP73-AS1 has been identified as a carcinogenic regulator of many malignancies. At the same time, the high expression of TP73-AS1 is related to the clinicopathological features of patients with cancer. It also regulates cell proliferation, anti-apoptosis, invasion and metastasis through a variety of potential mechanisms, suggesting that it may be a promising biomarker and therapeutic target for cancer. In this review, we summarize the biological functions, mechanisms, and potential clinical implications of TP73-AS1 dysregulation in tumourigenesis and progression.

Keywords: Cancers; Mechanisms; TP73-AS1; lncRNA.

Publication types

  • Review

MeSH terms

  • Apoptosis
  • Carcinogenesis / genetics
  • Cell Proliferation
  • Disease Progression
  • Humans
  • Neoplasm Invasiveness
  • Neoplasms / genetics*
  • RNA, Antisense / metabolism
  • RNA, Antisense / physiology*
  • RNA, Long Noncoding / physiology*
  • Tumor Protein p73 / genetics*

Substances

  • RNA, Antisense
  • RNA, Long Noncoding
  • TP73 protein, human
  • Tumor Protein p73