A Novel Coronavirus From Patients With Pneumonia in China, 2019

N Engl J Med. 2020 Feb 20;382(8):727-733. doi: 10.1056/NEJMoa2001017. Epub 2020 Jan 24.

Abstract

In December 2019, a cluster of patients with pneumonia of unknown cause was linked to a seafood wholesale market in Wuhan, China. A previously unknown betacoronavirus was discovered through the use of unbiased sequencing in samples from patients with pneumonia. Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily. Different from both MERS-CoV and SARS-CoV, 2019-nCoV is the seventh member of the family of coronaviruses that infect humans. Enhanced surveillance and further investigation are ongoing. (Funded by the National Key Research and Development Program of China and the National Major Project for Control and Prevention of Infectious Disease in China.).

MeSH terms

  • Adult
  • Betacoronavirus / genetics
  • Betacoronavirus / isolation & purification*
  • Betacoronavirus / ultrastructure
  • Bronchoalveolar Lavage Fluid / virology
  • Cells, Cultured
  • China
  • Coronavirus Infections / diagnostic imaging
  • Coronavirus Infections / pathology
  • Coronavirus Infections / virology*
  • Epithelial Cells / pathology
  • Epithelial Cells / virology
  • Female
  • Genome, Viral
  • Humans
  • Lung / diagnostic imaging*
  • Lung / pathology
  • Lung / virology
  • Male
  • Microscopy, Electron, Transmission
  • Middle Aged
  • Phylogeny
  • Pneumonia, Viral / diagnostic imaging
  • Pneumonia, Viral / pathology
  • Pneumonia, Viral / virology*
  • Radiography, Thoracic
  • Respiratory System / pathology
  • Respiratory System / virology

Supplementary concepts

  • COVID-19
  • severe acute respiratory syndrome coronavirus 2