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. 2020 Jan 22;9(2):92.
doi: 10.3390/antiox9020092.

Compared Phenolic Compound Contents of 22 Commercial Fruit and Vegetable Juices: Relationship to Ex-Vivo Vascular Reactivity and Potential in Vivo Projection

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Free PMC article

Compared Phenolic Compound Contents of 22 Commercial Fruit and Vegetable Juices: Relationship to Ex-Vivo Vascular Reactivity and Potential in Vivo Projection

Alexis Matute et al. Antioxidants (Basel). .
Free PMC article

Abstract

The real impact of polyphenol-rich vegetable and fruit juice intake on cardiovascular health remains a matter of controversy. In the present study, rat aorta segments immersed in an organ bath (OB) were used to explore whether the total polyphenol content and/or individual phenolic compound contents of 22 commercial vegetable (n = 3) and fruit juices [(citrus (n = 5), berries (n = 10), apple (n = 2), pineapple (n = 2)] might be associated with vascular tone. Red juices (particularly blackcurrant) and lemon juice caused the most marked vasorelaxation, its amplitude being endothelium dependent or not according to the volume ratio of juice to initial OB solution Vjuice/VOBS). At volume ratios 5% and 10%, both the juice and OB total polyphenol for all juices and total anthocyanin contents for berry juices significantly correlated with aorta vasorelaxation intensity. This was not the case for total or individual flavonols (except kaempferol) or for total or individual flavanols (except epigallocatechin gallate). If one relates our measured concentrations of individual phenolic compounds in OB to what is known about their physiological concentrations, and given our evidenced correlations between compound concentrations and vasorelaxation intensity, kaempferol, epigallocatechin gallate and peonidin-3-O-glucoside seem to emerge as the interesting phenolic compounds likely to be responsible for the potent vasorelaxation observed with fruit juices, and more particularly blackcurrant ones. Clinical investigation is required, however, to confirm our observations.

Keywords: fruit and vegetable juices; phenolic compounds; rat aorta; vasorelaxation effect.

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Examples of endothelial vasorelaxation activity in segments of rat aorta according to the volume of either blackcurrant (Jacoby) and Tomato (Carrefour) juices (respectively panels A and B) added to 20 mL initial organ bath solution (OBS). The following Vjuice/VOBS ratios were selected to evaluate the vasorelaxant effect as a function of total or individual concentrations of specific phenolic compounds: 1%, 5%, and 10%. Cumulative volumes of each fruit or vegetable juice were then added to reach a final volume of 2000 µL over a period of 1 h. E = endothelium.
Figure 2
Figure 2
Total polyphenol contents (TPC-J), expressed in µg gallic acid equivalents per milliliter (µg GAE/mL), of 22 commercial vegetable and fruit juices found in Belgian and French markets. GAE: gallic acid equivalents. 1: Tomato (Carrefour), 2: Tomato (Biotta), 3: Carrot (Biotta), 4: Orange d’Espagne (Carrefour), 5: Pure Orange (Vitamont), 6: Lemon (Bonneterre), 7: Grapefruit, 8: Pure Grapefruit (Vitamont), 9: Grape (Materne), 10: Pure Grape (Vitamont), 11: Pomegranate (Biotta), 12: Blackcurrant (Biotta), 13: Blackcurrant (Natreen), 14: Blackcurrant (Jacoby Bio), 15: Blackcurrant (Van Nahmen), 16: Blackcurrant (Schörl Nectar), 17: Blackcurrant (Gut and Günstig), 18: Blackcurrant (Jacoby), 19: Pineapple Juice (Carrefour), 20: Pineapple Juice (De Drie Wilgen), 21: Apple (Carrefour), and 22: Pure Apple (Vitamont).
Figure 3
Figure 3
Concentrations of individual anthocyanins (µg/mL) found in 10 commercial red fruit juices. Numbers in bold indicate total anthocyanin concentrations (µg/mL) in the juices. Pet, Pel, P, and M are not represented because of their low to zero concentrations in the juices. 9. Grape Materne (Carrefour), 10. Pure Grape (Vitamont), 11. Pomegranate (Biotta), 12. Blackcurrant (Biotta), 13. Blackcurrant (Natreen), 14. Blackcurrant (Jacoby Bio), 15. Blackcurrant (Van Nahmen), 16. Blackcurrant (Schörl Nectar), 17. Blackcurrant (Gut and Günstig), and 18. Blackcurrant (Jacoby).

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