Potassium channels in control of renal function

Pedro H Imenez Silva; Carsten A Wagner

doi:10.1016/j.kint.2019.10.029

Potassium channels in control of renal function

Kidney Int. 2020 Feb;97(2):253-255. doi: 10.1016/j.kint.2019.10.029.

Authors

Pedro H Imenez Silva¹, Carsten A Wagner²

Affiliations

¹ Institute of Physiology, University of Zurich, Zurich, Switzerland; National Center of Competence in Research NCCR Kidney.CH, Switzerland.
² Institute of Physiology, University of Zurich, Zurich, Switzerland; National Center of Competence in Research NCCR Kidney.CH, Switzerland. Electronic address: Wagnerca@access.uzh.ch.

PMID: 31980072
DOI: 10.1016/j.kint.2019.10.029

Abstract

Potassium channels are important to control membrane potential and drive epithelial transport processes. In this issue of Kidney International, Bignon et al. report the role of the Kir4.2 K⁺-channel, localized at the basolateral membrane of proximal tubules, in the reabsorption of bicarbonate and the modulation of renal ammoniagenesis. The findings have implications for our understanding of how the kidney reacts to hypokalemia, an acid load, and the metabolic acidosis of patients with advanced stages of chronic kidney disease.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Acid-Base Equilibrium
Ammonia
Animals
Bicarbonates
Humans
Hypokalemia*
Mice
Potassium*

Substances

Bicarbonates
Ammonia
Potassium