Refractory palmoplantar pustulosis succesfully treated with apremilast

Dermatol Ther. 2020 Mar;33(2):e13230. doi: 10.1111/dth.13230. Epub 2020 Feb 9.


Palmoplantar pustulosis is a chronic inflammatory disease which characterized by a eruption of sterile pustules on the palms and soles. Apremilast is an oral phosphodiesterase-4 inhibitor which is approved for the treatment of chronic plaque psoriasis and psoriatic arthritis. However, no clinical trial has been performed to confirm the efficacy of apremilast for palmoplantar pustulosis yet. Moreover, there are very few cases of this disease treated with apremilast. Herein, we describe a case of a refractory palmoplantar pustulosis succesfully treated with apremilast.

Keywords: inflammatory disorders; psoriasis; therapy-systemic.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Arthritis, Psoriatic*
  • Humans
  • Psoriasis* / diagnosis
  • Psoriasis* / drug therapy
  • Skin Diseases, Vesiculobullous*
  • Thalidomide / analogs & derivatives


  • Thalidomide
  • apremilast