Molecular epidemiology and evolution of Haemophilus influenzae

Shuxian Wen; Donghua Feng; Dingqiang Chen; Ling Yang; Zhenbo Xu

doi:10.1016/j.meegid.2020.104205

Molecular epidemiology and evolution of Haemophilus influenzae

Infect Genet Evol. 2020 Jun:80:104205. doi: 10.1016/j.meegid.2020.104205. Epub 2020 Jan 22.

Authors

Shuxian Wen¹, Donghua Feng¹, Dingqiang Chen², Ling Yang³, Zhenbo Xu⁴

Affiliations

¹ Department of Laboratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
² Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
³ Department of Laboratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. Electronic address: jykresearch@126.com.
⁴ School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou 510640, China; Department of Microbial Pathogenesis, University of Maryland, Baltimore 21201, USA; Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center), Guangzhou, China. Electronic address: zhenbo.xu@hotmail.com.

PMID: 31981610
DOI: 10.1016/j.meegid.2020.104205

Abstract

Haemophilus influenzae remains a common cause of illness in children worldwide. H. influenzae type b is the leading cause of bacterial meningitis in children before introduction of vaccination and is a common cause of pneumonia, epiglottis and septic arthritis. Since the implementation of the Hib conjugate vaccine, the non-typeable H. influenzae has rapidly decreased in respiratory and invasive infections in children and adults. However, the rate of antibiotic resistance of H. influenzae varies with region and period and is usually on the rise. In this review, typing of H. influenzae, virulence factors and resistance will be dissertated.

Keywords: Haemophilus influenzae; Resistance; Typing; Virulence.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Anti-Bacterial Agents / pharmacology
Biofilms
Drug Resistance, Bacterial
Evolution, Molecular*
Haemophilus Infections / epidemiology*
Haemophilus Infections / microbiology*
Haemophilus Infections / prevention & control
Haemophilus influenzae / classification*
Haemophilus influenzae / drug effects
Haemophilus influenzae / genetics*
Haemophilus influenzae / immunology
Haemophilus influenzae type b / genetics
Haemophilus influenzae type b / immunology
Humans
Molecular Epidemiology
Polysaccharides, Bacterial / immunology
Serotyping
Virulence / genetics
Virulence Factors / genetics
beta-Lactam Resistance

Substances

Anti-Bacterial Agents
Polysaccharides, Bacterial
Virulence Factors