Emerging molecular functions of microRNA-124: Cancer pathology and therapeutic implications

Pathol Res Pract. 2020 Mar;216(3):152827. doi: 10.1016/j.prp.2020.152827. Epub 2020 Jan 20.


MicroRNAs are characterized as small, single-stranded, non-coding RNA molecules that bind to their target mRNA to prevent protein synthesis. MicroRNAs regulate various normal processes; however, they are aberrantly regulated in many cancers. They control the expression of various genes, including cancer-related genes. This causes microRNAs to be considered as a good target for further investigations for designing novel therapeutic strategies. Since miR124 is known for some time already, it has a tumor-suppressing role in various cancers. Numerous studies indicate its definite roles in malignant processes such as epithelial-to-mesenchymal transition, cell cycle arrest, metastasis, cancer stem cell formation and induction of apoptosis. However, some studies have indicated a dual role for miR-124 in oncogenic processes like autophagy and multi-drug resistance. In this article, we will review recent researches on the biological functions and clinical implications of miR-124. Subsequently, we will discuss future perspectives in terms of the roles of this miRNA in cancers.

Keywords: Cancer; Drug; Leukemia; Target therapy; microRNA.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • MicroRNAs / genetics*
  • Neoplasms / genetics*
  • Neoplasms / pathology*


  • MIRN124 microRNA, human
  • MicroRNAs