Cancer Cell Membrane-Decorated Zeolitic-Imidazolate Frameworks Codelivering Cisplatin and Oleanolic Acid Induce Apoptosis and Reversed Multidrug Resistance on Bladder Carcinoma Cells

Dong Chen; Longbo Cai; Yihong Guo; Junyi Chen; Qiangli Gao; Junxian Yang; Yongfa Li

doi:10.1021/acsomega.9b02261

Cancer Cell Membrane-Decorated Zeolitic-Imidazolate Frameworks Codelivering Cisplatin and Oleanolic Acid Induce Apoptosis and Reversed Multidrug Resistance on Bladder Carcinoma Cells

ACS Omega. 2020 Jan 6;5(2):995-1002. doi: 10.1021/acsomega.9b02261. eCollection 2020 Jan 21.

Authors

Dong Chen¹, Longbo Cai¹, Yihong Guo¹, Junyi Chen¹, Qiangli Gao², Junxian Yang², Yongfa Li²

Affiliations

¹ Department of Urology, 2nd Affiliated Hospital of Fujian Medical University, Quanzhou City 362000, Fujian Province, China.
² Department of Urology, The Affiliated Puren Hospital of Wuhan University of Science and Technology, No. 1 Benxi Street, the Fourth Jianshe Road, Qingshan District, Wuhan 430080, China.

Abstract

Combination therapy is emerging as a preferable approach in cancer therapy with minimized side effects and elevated performance. Nevertheless, the poor targeting and drug loading of currently available drug delivery systems (DDSs) are the main difficulties to realize preferable combination therapy of cancer. As a result, a cancer cell membrane-decorated zeolitic-imidazolate framework hybrid nanoparticle (HP) was successfully constructed in our study to codeliver cisplatin (DDP) and oleanolic acid (OLA). Our results showed positive results of the platform (HP/DDP/OLA) for the treatment of bladder cancer (SW780). In detail, HP/DDP/OLA could enhance apoptosis while reverse multidrug resistance in SW780 cells than free drugs alone or monodelivery systems, which might be a suitable DDS for codelivery of different drugs with great promise.