Genetic variations in MicroRNA genes and cancer risk: A field synopsis and meta-analysis

doi:10.1111/eci.13203

Review

. 2020 Apr;50(4):e13203.

doi: 10.1111/eci.13203. Epub 2020 Mar 6.

Genetic variations in MicroRNA genes and cancer risk: A field synopsis and meta-analysis

Jae Hyon Park¹, Gwang Hun Jeong², Kwang Seob Lee¹, Keum Hwa Lee^{3

4

5}, Jin-Soon Suh⁶, Michael Eisenhut⁷, Hans J van der Vliet⁸, Andreas Kronbichler⁹, Brendon Stubbs^{10

11

12}, Marco Solmi¹³, Elena Dragioti¹⁴, Ai Koyanagi^{15

16}, Jae Il Shin^{3

4

5}, Gabriele Gamerith^{17

18}

Affiliations

¹ Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
² College of Medicine, Gyeongsang National University, Jinju, Korea.
³ Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
⁴ Division of Pediatric Nephrology, Severance Children's Hospital, Seoul, Korea.
⁵ Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Korea.
⁶ Department of Pediatrics, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
⁷ Luton & Dunstable University Hospital NHS Foundation Trust, Luton, UK.
⁸ Department of Medical Oncology, Amsterdam UMC, Cancer Center Amsterdam, VU University, Amsterdam, The Netherlands.
⁹ Department of Internal Medicine IV (Nephrology and Hypertension), Medical University of Innsbruck, Innsbruck, Austria.
¹⁰ Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
¹¹ South London and Maudsley NHS Foundation Trust, London, UK.
¹² Faculty of Health, Social Care and Education, Anglia Ruskin University, Chelmsford, UK.
¹³ Department of Neuroscience, University of Padova, Padova, Italy.
¹⁴ Pain and Rehabilitation Centre, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
¹⁵ Parc Sanitari Sant Joan de Déu/CIBERSAM, Universitat de Barcelona, Fundació Sant Joan de Déu, Sant Boi de Llobregat, Barcelona, Spain.
¹⁶ ICREA, Pg. Lluis Companys 23, Barcelona, Spain.
¹⁷ Department of Internal Medicine V (Hematology and Oncology), Medical University of Innsbruck, Innsbruck, Austria.
¹⁸ Tyrolean Cancer Research Institute, Innsbruck, Austria.

PMID: 31984489
DOI: 10.1111/eci.13203

Review

Genetic variations in MicroRNA genes and cancer risk: A field synopsis and meta-analysis

Jae Hyon Park et al. Eur J Clin Invest. 2020 Apr.

. 2020 Apr;50(4):e13203.

doi: 10.1111/eci.13203. Epub 2020 Mar 6.

Authors

Affiliations

¹ Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
² College of Medicine, Gyeongsang National University, Jinju, Korea.
³ Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
⁴ Division of Pediatric Nephrology, Severance Children's Hospital, Seoul, Korea.
⁵ Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Korea.
⁶ Department of Pediatrics, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
⁷ Luton & Dunstable University Hospital NHS Foundation Trust, Luton, UK.
⁸ Department of Medical Oncology, Amsterdam UMC, Cancer Center Amsterdam, VU University, Amsterdam, The Netherlands.
⁹ Department of Internal Medicine IV (Nephrology and Hypertension), Medical University of Innsbruck, Innsbruck, Austria.
¹⁰ Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
¹¹ South London and Maudsley NHS Foundation Trust, London, UK.
¹² Faculty of Health, Social Care and Education, Anglia Ruskin University, Chelmsford, UK.
¹³ Department of Neuroscience, University of Padova, Padova, Italy.
¹⁴ Pain and Rehabilitation Centre, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
¹⁵ Parc Sanitari Sant Joan de Déu/CIBERSAM, Universitat de Barcelona, Fundació Sant Joan de Déu, Sant Boi de Llobregat, Barcelona, Spain.
¹⁶ ICREA, Pg. Lluis Companys 23, Barcelona, Spain.
¹⁷ Department of Internal Medicine V (Hematology and Oncology), Medical University of Innsbruck, Innsbruck, Austria.
¹⁸ Tyrolean Cancer Research Institute, Innsbruck, Austria.

PMID: 31984489
DOI: 10.1111/eci.13203

Abstract

Background: Cancer risk has been associated with certain gene variations in microRNA (miRNA), but conflicting evidence warrants re-assessing of significant results in meta-analyses. We summarized published meta-analyses that assess the associations between miRNA polymorphism and cancers to show the validity of the findings.

Method: We searched PubMed and investigated the results of meta-analyses published through November 2018. We re-assessed the results based on false-positive report probability (FPRP) to test the noteworthiness of the associations.

Results: Sixty-eight miRNA polymorphisms in 45 meta-analyses associated with cancer were included. Four (7.4%) and sixteen (25.0%) single nucleotide polymorphisms (SNPs) were noteworthy (FPRP < 0.2) at a prior probability of 0.001 for interesting candidate genes and a statistical power to detect an odds ratio (OR) of 1.1 and 1.5, respectively. The four miRNA SNPs noteworthy at an OR of 1.1 were as follows: miR-146a/rs2910164 Cvs.G; miR-27a/rs895819 Cvs.T; miR-423/rs6505162 Cvs.A; and miR-605/rs2043556 Cvs.T. The 16 SNPs noteworthy at an OR of 1.5 include the four genotype comparisons at an OR of 1.1, and the additional 12 genotype comparisons were as follows: miR-196a2/rs11614913 Tvs.C; miR-27a/rs895819 GGvs.AA + AG; miR-196a2/rs11614913 C vs.T; miR-146a/rs2910164 Gvs.C; miR-196a2/rs11614913 Tvs.C; miR-146a/rs2910164 Cvs.G; miR-499/rs3746444 homozygous model; miR-146a/rs2910164 CCvs.GG + GC; miR-499/rs3746444 TCvs.TT; miR-499/rs3746444 GAvs.AA; miR-146a/rs2910164 CCvs.GG; and miR-499/rs3746444 Gvs.A. No association was noteworthy at a prior probability of 0.000001.

Conclusion: Out of 68 published associations of miRNA polymorphisms with cancer, sixteen have shown noteworthiness in our re-assessing meta-analysis. Our findings summarize the results of meta-analyses on the association of cancer with SNPs and underline the importance of interpreting results with caution.

Keywords: FPRP; cancer; gene variant; meta-analysis; microRNA.

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References

REFERENCES

1. Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer. 2006;6(11):857-866.
1. Gu S, Kay MA. How do miRNAs mediate translational repression? Silence. 2010;1(1):11.
1. Claus EB, Schildkraut JM, Thompson WD, Risch NJ. The genetic attributable risk of breast and ovarian cancer. Cancer. 1996;77(11):2318-2324.
1. Ryan BM, Robles AI, Harris CC. Genetic variation in microRNA networks: the implications for cancer research. Nat Rev Cancer. 2010;10(6):389-402.
1. Hayes J, Peruzzi PP, Lawler S. MicroRNAs in cancer: biomarkers, functions and therapy. Trends Mol Med. 2014;20(8):460-469.

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[1] Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer. 2006;6(11):857-866.

[2] Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer. 2006;6(11):857-866.

[3] Gu S, Kay MA. How do miRNAs mediate translational repression? Silence. 2010;1(1):11.

[4] Gu S, Kay MA. How do miRNAs mediate translational repression? Silence. 2010;1(1):11.

[5] Claus EB, Schildkraut JM, Thompson WD, Risch NJ. The genetic attributable risk of breast and ovarian cancer. Cancer. 1996;77(11):2318-2324.

[6] Claus EB, Schildkraut JM, Thompson WD, Risch NJ. The genetic attributable risk of breast and ovarian cancer. Cancer. 1996;77(11):2318-2324.

[7] Ryan BM, Robles AI, Harris CC. Genetic variation in microRNA networks: the implications for cancer research. Nat Rev Cancer. 2010;10(6):389-402.

[8] Ryan BM, Robles AI, Harris CC. Genetic variation in microRNA networks: the implications for cancer research. Nat Rev Cancer. 2010;10(6):389-402.

[9] Hayes J, Peruzzi PP, Lawler S. MicroRNAs in cancer: biomarkers, functions and therapy. Trends Mol Med. 2014;20(8):460-469.

[10] Hayes J, Peruzzi PP, Lawler S. MicroRNAs in cancer: biomarkers, functions and therapy. Trends Mol Med. 2014;20(8):460-469.

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Genetic variations in MicroRNA genes and cancer risk: A field synopsis and meta-analysis

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Genetic variations in MicroRNA genes and cancer risk: A field synopsis and meta-analysis

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