Age-Specific Incidence of Influenza A Responds to Change in Virus Subtype Dominance

Alain Gagnon; Enrique Acosta; Matthew S Miller

doi:10.1093/cid/ciaa075

Age-Specific Incidence of Influenza A Responds to Change in Virus Subtype Dominance

Clin Infect Dis. 2020 Oct 23;71(7):e195-e198. doi: 10.1093/cid/ciaa075.

Authors

Alain Gagnon^{1

2}, Enrique Acosta^{1

3}, Matthew S Miller⁴

Affiliations

¹ Département de démographie, Université de Montréal, Montreal, Canada.
² Centre de recherche en santé publique, Montreal, Canada.
³ Max Planck Institute for Demographic Research, Rostock, Germany.
⁴ Department of Biochemistry and Biomedical Sciences, Michael G. DeGroote Institute for Infectious Disease Research, McMaster Immunology Research Centre, McMaster University, Hamilton, Canada.

PMID: 31985006
DOI: 10.1093/cid/ciaa075

Abstract

When H3N2 replaced H1N1 as the dominant influenza A subtype during the 2018-2019 season, the pattern of age-specific incidence shifted due to the lingering effects of antigenic imprinting. The characteristic shape that imprinting leaves on influenza susceptibility could foster important advances in understanding and predicting the epidemiology of influenza.

Keywords: age-specific analysis; antigenic imprinting; cohort effect; influenza incidence.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Age Factors
Hemagglutinin Glycoproteins, Influenza Virus
Humans
Incidence
Influenza A Virus, H1N1 Subtype*
Influenza A Virus, H3N2 Subtype
Influenza, Human* / epidemiology
Seasons

Substances

Hemagglutinin Glycoproteins, Influenza Virus

Grants and funding

367129/CIHR/Canada