Multicenter Perioperative Outcomes Group Enhanced Observation Study Postoperative Pain Profiles, Analgesic Use, and Transition to Chronic Pain and Excessive and Prolonged Opioid Use Patterns Methodology

Anesth Analg. 2020 Jun;130(6):1702-1708. doi: 10.1213/ANE.0000000000004568.


To study the impact of anesthesia opioid-related outcomes and acute and chronic postsurgical pain, we organized a multicenter study that comprehensively combined detailed perioperative data elements from multiple institutions. By combining pre- and postoperative patient-reported outcomes with automatically extracted high-resolution intraoperative data obtained through the Multicenter Perioperative Outcomes Group (MPOG), the authors sought to describe the impact of patient characteristics, preoperative psychological factors, surgical procedure, anesthetic course, postoperative pain management, and postdischarge pain management on postdischarge pain profiles and opioid consumption patterns. This study is unique in that it utilized multicenter prospective data collection using a digital case report form integrated with the MPOG framework and database. Therefore, the study serves as a model for future studies using this innovative method. Full results will be reported in future articles; the purpose of this article is to describe the methods of this study.

Publication types

  • Multicenter Study
  • Observational Study
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Analgesics / therapeutic use*
  • Analgesics, Opioid / therapeutic use*
  • Anxiety / complications
  • Anxiety / diagnosis
  • Chronic Pain / therapy*
  • Depression / complications
  • Depression / diagnosis
  • Humans
  • Opioid-Related Disorders / prevention & control
  • Pain Management / methods*
  • Pain Measurement
  • Pain, Postoperative / drug therapy*
  • Postoperative Period
  • Prospective Studies
  • Self Report
  • Surveys and Questionnaires
  • Treatment Outcome


  • Analgesics
  • Analgesics, Opioid