Targeting Tanycytes: Balance between Efficiency and Specificity

Neuroendocrinology. 2020;110(7-8):574-581. doi: 10.1159/000505549. Epub 2020 Jan 2.

Abstract

Tanycytes are peculiar ependymoglial cells lining the bottom and the lateral wall of the third ventricle. For a decade, the utilization of molecular genetic approaches allowed us to make important discoveries about their diverse physiological functions. Here, I review the current methods used to target tanycytes, focusing on their specificity, their efficiency, their limitations, as well as their potential future improvements.

Keywords: Adeno-associated virus; Adenoviruses; CreERT2; Genetic manipulation; Hypothalamus; Median eminence; TAT-Cre; Tanycytes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Drug Delivery Systems / methods
  • Ependymoglial Cells / cytology*
  • Ependymoglial Cells / metabolism
  • Ependymoglial Cells / physiology*
  • Gene Expression Regulation
  • Gene Targeting / methods*
  • Humans
  • Sensitivity and Specificity
  • Third Ventricle