Craniorachischisis with Exencephaly

Fetal Pediatr Pathol. 2021 Oct;40(5):501-504. doi: 10.1080/15513815.2020.1716282. Epub 2020 Jan 27.


Neural tube defects can be as mild as spina bifida, to as severe as anencephaly, with only a fraction of these cases presenting as both craniorachischisis and exencephaly. Case report: The G3, P1011 mother was 25-years old, who at an estimated fetal gestational age of 17 weeks had a fetal diagnosis of anencephaly based on a sonogram, resulting in elective pregnancy termination. The female fetus had an open neural tube defect, consisting of craniorachischisis and exencephaly. No abnormalities were noted in any other organs. Conclusion: Although mostly associated with anencephaly, craniorachischisis can also be associated with exencephaly in early pregnancy.

Keywords: anencephaly; craniorachischisis; exencephaly; fetal pathology; neural tube defect.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anencephaly* / diagnostic imaging
  • Female
  • Fetus
  • Humans
  • Neural Tube Defects* / complications
  • Pregnancy
  • Prenatal Diagnosis
  • Spinal Dysraphism*