Objective: Glucose disorders and dyslipidemia are closely associated with obesity and metabolic disease. The purpose of this study was to investigate the effect of Carnosine supplementation on lipid profile, fasting blood glucose, HbA1C and Insulin resistance.
Method: MEDLINE/PubMed, Scopus and Web of sciences were investigated to identify relevant articles up to June 2019. The search strategy combined the Medical Subject Heading and Title and/or abstract keywords. The combined effect sizes were calculated as weight mean difference (WMD) using the random-effects model. Between study heterogeneity was evaluated by the Cochran's Q test and I2.
Results: Four RCTs studies investigated Carnosine use versus any control for at least 2 weeks were identified and analyzed. Overall results from the random-effects model on included studies, with 184 participants, indicated that carnosine intervention reduced HbA1C levels in intervention vs control groups (WMD: -0.92 %, 95 % CI: -1.20, -0.63, I2:69 %). Four studies, including a total of 183 participants, reported TG changes as an outcome measure variable, but combined results did not show significant reduction in this outcome (WMD: -14.46 mg/dl, 95 % CI: -29.11, 0.19, I2:94 %). Furthermore, combined results did not show any significant change in HOMA-IR, Cholesterol, fasting blood sugar, or HDL-C.
Conclusion: Carnosine supplementation results in a decrease in HbA1C, but elicits no effect on HOMA-IR, Cholesterol, fasting blood sugar, TG and HDL-C. Future studies with a larger sample sizes, varied doses of carnosine, and population-specific sub-groups are warranted to confirm, and enhance, the veracity of our findings.
Keywords: Carnosine; Cholesterol; Fasting blood sugar; HbA1C.
Copyright © 2019. Published by Elsevier Ltd.
The Effects of Carnitine Supplementation on Clinical Characteristics of Patients With Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsM Abolfathi et al. Complement Ther Med 48, 102273. PMID 31987257. - ReviewThis analysis shows that carnitine supplementation for patients with nonalcoholic fatty liver disease demonstrates a reduction in AST, ALT, TG levels and HOMA-IR. However …
The Effects of Vitamin D Treatment on Glycemic Control, Serum Lipid Profiles, and C-reactive Protein in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsA Milajerdi et al. Int Urol Nephrol 51 (9), 1567-1580. PMID 31338797. - Meta-AnalysisThis meta-analysis demonstrated the beneficial effects of vitamin D supplementation or treatment on improving fasting glucose, HOMA-IR, triglycerides and cholesterol leve …
The Effect of L-Carnitine Supplementation on Lipid Profile and Glycaemic Control in Adults With Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical TrialsM Asadi et al. Clin Nutr 39 (1), 110-122. PMID 30850271.This meta-analysis showed that l-carnitine supplementation could improve lipid profile levels, particularly in doses more than 1500 mg/day. More RCTs with large sample si …
Effect of Folate Supplementation on Insulin Sensitivity and Type 2 Diabetes: A Meta-Analysis of Randomized Controlled TrialsMV Lind et al. Am J Clin Nutr 109 (1), 29-42. PMID 30615110. - Meta-AnalysisFolate supplementation might be beneficial for glucose homeostasis and lowering IR, but at present there are insufficient data to conclusively determine the effect on dev …
Continuous Subcutaneous Insulin Infusion (CSII) Pumps for Type 1 and Type 2 Adult Diabetic Populations: An Evidence-Based AnalysisMedical Advisory Secretariat. Ont Health Technol Assess Ser 9 (20), 1-58. PMID 23074525.The database search identified 519 relevant citations published between 1996 and March 24, 2009. Of the 519 abstracts reviewed, four RCTs and one abstract met the inclusi …