Abstract
Background:
Thoracic endometriosis syndrome (TES) is a rare condition that occurs in women when endometriosis implants into the thoracic cavity. Catamenial hemoptysis, the occurrence of hemoptysis with menstruation, is a recognized clinical manifestation of TES commonly treated with hormonal therapy.
Case summary:
We present the first documented case describing the recrudescence of catamenial hemoptysis in the setting of Lumacaftor/Ivacaftor administration in a 25-year-old woman with cystic fibrosis (CF).
Discussion:
We review the literature on TES, pharmacologic management, and reported cystic fibrosis transmembrane conductance regulator (CFTR) modulator drug interactions. We propose that our patient's recrudescence of catamenial hemoptysis was secondary to a drug-drug interaction between Lumacaftor/Ivacaftor and oral contraceptive therapy.
Conclusion:
Our case suggests that women with CF who have catamenial hemoptysis and a genetic mutation approved for Tezacaftor/Ivacaftor or Elexacaftor/Tezacaftor/Ivacaftor can be managed effectively with either CFTR modulator and hormonal contraceptive therapy.
Keywords:
CFTR modulators; Hemoptysis; Women's health.
Copyright © 2020. Published by Elsevier B.V.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aminophenols / therapeutic use*
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Aminopyridines / therapeutic use*
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Benzodioxoles / therapeutic use*
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Bronchoscopy / methods
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Chloride Channel Agonists / therapeutic use
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Cystic Fibrosis* / complications
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Cystic Fibrosis* / diagnosis
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Cystic Fibrosis* / drug therapy
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Cystic Fibrosis* / physiopathology
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Drug Combinations
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Drug Therapy, Combination / methods
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Endometriosis* / complications
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Endometriosis* / diagnosis
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Endometriosis* / drug therapy
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Endometriosis* / physiopathology
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Female
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Fertility Agents, Female / administration & dosage
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Hemoptysis* / diagnosis
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Hemoptysis* / etiology
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Hemoptysis* / prevention & control
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Humans
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Indoles / therapeutic use*
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Leuprolide / administration & dosage*
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Pyrazoles / therapeutic use*
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Pyridines / therapeutic use*
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Quinolines / therapeutic use*
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Quinolones / therapeutic use*
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Radiography, Thoracic / methods
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Thoracic Diseases / complications
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Thoracic Diseases / diagnosis
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Thoracic Diseases / drug therapy
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Thoracic Diseases / physiopathology
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Tomography, X-Ray Computed / methods
Substances
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Aminophenols
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Aminopyridines
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Benzodioxoles
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Chloride Channel Agonists
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Drug Combinations
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Fertility Agents, Female
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Indoles
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Pyrazoles
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Pyridines
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Quinolines
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Quinolones
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elexacaftor, ivacaftor, tezacaftor drug combination
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lumacaftor, ivacaftor drug combination
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Leuprolide