Post-translational modification of baculovirus-encoded proteins

Virus Res. 2020 Apr 2:279:197865. doi: 10.1016/j.virusres.2020.197865. Epub 2020 Jan 24.


Post-translational modifications (PTMs) are the chemical modifications of proteins after translation, and are very important to guarantee the proper biological functions of these proteins. Baculoviruses are pathogenic viruses that infect invertebrates and have large circular double-stranded DNA genomes. Many proteins encoded by baculoviruses have been reported to have PTMs, including phosphorylation, glycosylation, ubiquitination, acetylation, and etc. However, up to now no overview of this information has been produced. In this review, we have summarized the PTMs that have been reported in baculovirus. As a majority of the studies on baculovirus have focused on Autographa californica multiple nucleopolyhedrovirus (AcMNPV) and Bombyx mori nucleopolyhedrovirus(BmNPV), this review is focused primarily on these viruses.

Keywords: AcMNPV; BmNPV; Post-Translational modification; Proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Larva
  • Nucleopolyhedroviruses / genetics*
  • Nucleopolyhedroviruses / physiology
  • Protein Processing, Post-Translational*
  • Viral Proteins / chemistry*
  • Viral Proteins / genetics
  • Virus Replication


  • Viral Proteins

Supplementary concepts

  • Autographa californica multiple nuclear polyhedrosis virus
  • Bombyx mori nucleopolyhedrovirus