Cancer during HIV infection

APMIS. 2020 Feb;128(2):121-128. doi: 10.1111/apm.13020. Epub 2020 Jan 28.


HIV+ persons have a significantly increased risk of cancer when compared to the general population. The excess cancer risk observed during HIV infection is particularly higher for infection-related malignancies. Mechanisms underlying this remain unclear, but both HIV-related and HIV-unrelated factors have been postulated to play a role. Here, we (i) review newly published data on cancer burden in the setting of HIV infection with a focus on HIV-related risk factors for cancer; (ii) discuss emerging data on cancer among HIV+ persons living in low- and middle-income countries; and (iii) review guideline recommendations for cancer screening among HIV+ persons and discuss ongoing studies investigating strategies for cancer screening among HIV+ patients.

Keywords: AIDS; HIV; antiretroviral therapy; cancer; screening.

Publication types

  • Review

MeSH terms

  • Early Detection of Cancer / methods
  • HIV Infections / complications*
  • Humans
  • Neoplasms / etiology*
  • Neoplasms / virology*
  • Risk Factors