First-Trimester Pregnancy Exposure to Modafinil and Risk of Congenital Malformations

JAMA. 2020 Jan 28;323(4):374-376. doi: 10.1001/jama.2019.20008.

Abstract

This study uses pharmacoepidemiology data from Danish national health registries to examine the association between first-trimester exposure to modafinil and risk of major congenital malformations.

Publication types

  • Comparative Study

MeSH terms

  • Abnormalities, Drug-Induced / epidemiology*
  • Abnormalities, Drug-Induced / etiology
  • Adult
  • Central Nervous System Stimulants / adverse effects*
  • Denmark / epidemiology
  • Female
  • Humans
  • Logistic Models
  • Methylphenidate / adverse effects*
  • Modafinil / adverse effects*
  • Pregnancy
  • Pregnancy Trimester, First
  • Product Surveillance, Postmarketing
  • Registries

Substances

  • Central Nervous System Stimulants
  • Methylphenidate
  • Modafinil