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. 2019 Dec 15;11(6):267-273.
eCollection 2019.

Serum levels of IL-6 and IL-17 in multiple sclerosis, neuromyelitis optica patients and healthy subjects

Fereshte Ashtari  1   2 , Reyhanehsadat Madanian  1   2 , Vahid Shaygannejad  1   2 , Sayyed Hamid Zarkesh  3 , Keyvan Ghadimi  4
Affiliations

Serum levels of IL-6 and IL-17 in multiple sclerosis, neuromyelitis optica patients and healthy subjects

Fereshte Ashtari et al. Int J Physiol Pathophysiol Pharmacol. .

Abstract

Background: Studies reported that evaluating the interleukin serum level of MS and NMO patients is helpful for differentiating these two diseases from each other. This study aimed to compare the level of IL-6 and IL-17 in MS and NMO patients and healthy subjects.

Methods: This study is a case control study that evaluated the serum level of IL-6 and IL-17 in MS and NMO patients in comparison to controls in patients who referred to Kashani hospital clinics. The level of serum IL-6 and IL-17 were measured by ELISA test in all patients. Participants were divided in to three groups include MS patients, NMO patients and controls and the level of IL-6 and IL-17 were compared in this three groups.

Results: Mean of serum level of IL-6 in the NMO group was significantly lower than MS and healthy subject (P=0.02 for NMO and MS, P=0.001 for NMO and healthy subjects) but there was no significant difference between MS and healthy subjects (P=0.09). The mean of serum level of IL-17 in the MS and NMO were significantly higher than healthy subjects (P<0.001 for both). Also the mean of serum level of IL-17 in the MS was significantly higher than NMO (P=0.01). A positive significant correlation between age and serum level of IL-6 in all subjects (r=0.23, P=0.01). There was a positive significant correlation between age and serum level of IL-17 in MS and NMO patients (r=0.28, P=0.012).

Conclusion: Using IL-17 and IL-6 were inflammatory markers to diagnosis of NMO, MS and healthy subjects.

Keywords: Multiple sclerosis; interleukin; neuromyelitis optica (NMO).

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Boxplot of serum level of IL-6 levels in MS, NMO and healthy subject based on gender. The mean of serum level of IL-6 in NMO patients was significantly lower than MS and healthy subjects (One-way ANOVA).
Figure 2
Figure 2
Boxplot of serum level of IL-17 levels in MS, NMO and healthy subject based on gender that the mean of IL-17 in healthy subjects was significantly lower than NMO and MS patients based one-way ANOVA.
Figure 3
Figure 3
Positive significant correlation or direct relation between age and serum level of IL-6 in MS, NMO and healthy subjects based on Pearson correlation.
Figure 4
Figure 4
Positive significant correlation between age and serum level of IL-17 in MS and NMO patients based on Pearson correlation.
See this image and copyright information in PMC

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