Coexisting mutations in CARD14 and NUDT15 detected in a young female with azathioprine hypersensitivity syndrome manifested as acute generalized exanthematous pustulosis

J Dermatol. 2020 Apr;47(4):e109-e110. doi: 10.1111/1346-8138.15240. Epub 2020 Jan 28.

Authors

Chih-Yu Chen¹, Chien-Ping Chiang^{1

2}, Hsiang-Cheng Chen³, Hong-Wei Gao⁴, Wei-Ming Wang¹, Chih-Tsung Hung^{1

5}

Affiliations

¹ Department of Dermatology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
² Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan.
³ Division of Rheumatology/Immunology/Allergy, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
⁴ Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
⁵ Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan.

PMID: 31994212
DOI: 10.1111/1346-8138.15240

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Acute Generalized Exanthematous Pustulosis / diagnosis
Acute Generalized Exanthematous Pustulosis / genetics*
Acute Generalized Exanthematous Pustulosis / immunology
Acute Generalized Exanthematous Pustulosis / pathology
Adult
Azathioprine / adverse effects*
Azathioprine / pharmacokinetics
CARD Signaling Adaptor Proteins / genetics*
CARD Signaling Adaptor Proteins / immunology
DNA Mutational Analysis
Drug Hypersensitivity Syndrome / diagnosis
Drug Hypersensitivity Syndrome / genetics*
Drug Hypersensitivity Syndrome / immunology
Drug Hypersensitivity Syndrome / pathology
Female
Guanylate Cyclase / genetics*
Guanylate Cyclase / immunology
Humans
Membrane Proteins / genetics*
Membrane Proteins / immunology
Mutation
Pyrophosphatases / genetics*
Pyrophosphatases / metabolism
Skin / immunology
Skin / pathology

Substances

CARD Signaling Adaptor Proteins
Membrane Proteins
NUDT15 protein, human
Pyrophosphatases
CARD14 protein, human
Guanylate Cyclase
Azathioprine