Effects of exercise on residual renal function in patients undergoing peritoneal dialysis: A post-hoc analysis of a randomized controlled trial

Ther Apher Dial. 2020 Dec;24(6):668-676. doi: 10.1111/1744-9987.13481. Epub 2020 Mar 7.


We aimed to investigate the effects of exercise on renal outcomes in patients undergoing peritoneal dialysis (PD). In a post-hoc analysis of a randomized controlled trial of a 12-week home-based exercise program involving 47 patients undergoing PD, we excluded 18 patients with anuria and analyzed 13 and 16 patients in the usual care and exercise groups, respectively. The primary outcomes were weekly renal creatinine clearance (CCr) and urinary biomarkers: liver-type fatty acid-binding protein (L-FABP) and the microalbumin-to-creatinine ratio (ACR). Although the maintenance of weekly renal CCr in the exercise group was not significantly different compared with that in the usual care group (P = .09), urinary L-FABP levels (P = .02) and ACR (P = .04) were significantly decreased in the exercise group. To the best of our knowledge, this is the first study to demonstrate the beneficial effects of exercise on renal outcomes in patients undergoing PD.

Keywords: exercise; liver-type fatty acid-binding protein; microalbumin-to-creatinine ratio; peritoneal dialysis; residual renal function.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Biomarkers / analysis
  • Creatinine / analysis
  • Exercise Therapy / methods*
  • Fatty Acid-Binding Proteins / blood*
  • Female
  • Home Care Services
  • Humans
  • Kidney Failure, Chronic* / metabolism
  • Kidney Failure, Chronic* / physiopathology
  • Kidney Failure, Chronic* / therapy
  • Kidney Function Tests / methods
  • Male
  • Middle Aged
  • Outcome and Process Assessment, Health Care
  • Peritoneal Dialysis / methods*
  • Physical Functional Performance
  • Renal Elimination


  • Biomarkers
  • FABP1 protein, human
  • Fatty Acid-Binding Proteins
  • Creatinine