Neurotoxicities associated with checkpoint inhibitors: Two case reports and a review of the literature

Clin Case Rep. 2019 Nov 26;8(1):24-32. doi: 10.1002/ccr3.2534. eCollection 2020 Jan.


We report a case of nivolumab-induced delayed-onset aseptic meningitis and a case of limbic encephalitis and peripheral nerve palsy with toxicity relapse 6 months after initial presentation. The atypical presentations contribute to our knowledge of these rare events and reinforce the necessity for vigilant monitoring and a multidisciplinary treatment approach.

Keywords: aseptic meningitis; checkpoint inhibitor; encephalitis; ipilimumab; neurotoxicity; nivolumab.

Publication types

  • Case Reports