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Review
, 10 (1), 91-104

New Insights of CYP1A in Endogenous Metabolism: A Focus on Single Nucleotide Polymorphisms and Diseases

Affiliations
Review

New Insights of CYP1A in Endogenous Metabolism: A Focus on Single Nucleotide Polymorphisms and Diseases

Jian Lu et al. Acta Pharm Sin B.

Abstract

Cytochrome P450 1A (CYP1A), one of the major CYP subfamily in humans, not only metabolizes xenobiotics including clinical drugs and pollutants in the environment, but also mediates the biotransformation of important endogenous substances. In particular, some single nucleotide polymorphisms (SNPs) for CYP1A genes may affect the metabolic ability of endogenous substances, leading to some physiological or pathological changes in humans. This review first summarizes the metabolism of endogenous substances by CYP1A, and then introduces the research progress of CYP1A SNPs, especially the research related to human diseases. Finally, the relationship between SNPs and diseases is discussed. In addition, potential animal models for CYP1A gene editing are summarized. In conclusion, CYP1A plays an important role in maintaining the health in the body.

Keywords: CYP, cytochrome P450; CYP1A; EOAs, cis-epoxyoctadecenoics; Endogenous substances; FSH, follicle stimulating hormone; HODEs, hydroxyoctadecdienoic acids; IQ, 2-amino-3-methylimidazo [4,5-f] quinoline; KO, knockout; LIF/STAT3, inhibiting leukemia inhibitory factor/signal transducer and activator of transcription 3; Metabolism and disease; PhIP, 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine; SNPs; SNPs, single nucleotide polymorphisms; WT, wild type; Xenobiotics; t-RA, all-trans-retinoic acid; t-ROH, all-trans-retinol.

Figures

Image 1
Figure 1
Figure 1
CYP1A-mediated metabolism of progestogens.
Figure 2
Figure 2
CYP1A-mediated metabolism of estrogens and estradiol 3-methyl ether. (A) CYP1A-mediated metabolism of estrogens. (B) CYP1A-mediated metabolism of estradiol 3-methyl ether.
Figure 3
Figure 3
CYP1A-mediated metabolism of melatonin (A), t-RAL (B) and linoleic acid (C). t-ROH, all-trans-retinol; t-RAL, all-trans-retinal; t-RA, all-trans-retinoic acid; EOA, cis-epoxyoctadecenoic; HODE, hydroxyoctadecdienoic acid.
Figure 4
Figure 4
CYP1A-mediated metabolism of uroporphyrinogen (A) and phosphatidylcholine (B).

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