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. 2020 Feb;18(2):278-284.
doi: 10.1111/jth.14671.

The Prevention and Management of Asparaginase-Related Venous Thromboembolism in Adults: Guidance From the SSC on Hemostasis and Malignancy of the ISTH

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The Prevention and Management of Asparaginase-Related Venous Thromboembolism in Adults: Guidance From the SSC on Hemostasis and Malignancy of the ISTH

Jeffrey I Zwicker et al. J Thromb Haemost. .

Abstract

Venous thromboembolism is a common complication of asparaginase-based chemotherapy regimens for the treatment of acute lymphoblastic leukemia. Thrombosis associated with asparaginase administration poses a number of specific and often clinically challenging management decisions. This review provides guidance on the prevention and treatment of thrombosis associated with asparaginase in adults including discussions on antithrombin repletion, pharmacologic thromboprophylaxis, cerebral venous thrombosis, and therapeutic anticoagulation.

Keywords: acute lymphoblastic leukemia; anticoagulation; antithrombin; asparaginase; cerebral venous thrombosis; venous thromboembolism.

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References

REFERENCES

    1. Angiolillo AL, Schore RJ, Devidas M, et al. Pharmacokinetic and pharmacodynamic properties of calaspargase pegol Escherichia coli L-asparaginase in the treatment of patients with acute lymphoblastic leukemia: results from Children's Oncology Group Study AALL07P4. J Clin Oncol. 2014;32:3874-3882.
    1. National Comprehensive Cancer Network. Acute Lymphocytic Leukemia (Version 2.2019). 2019.
    1. De Stefano V, Za T, Ciminello A, Betti S, Rossi E. Haemostatic alterations induced by treatment with asparaginases and clinical consequences. Thromb Haemost. 2015;113:247-261.
    1. Stock W, Douer D, DeAngelo DJ, et al. Prevention and management of asparaginase/pegasparaginase-associated toxicities in adults and older adolescents: recommendations of an expert panel. Leuk Lymphoma. 2011;52:2237-2253.
    1. Stock W, Luger SM, Advani AS, et al. A pediatric regimen for older adolescents and young adults with acute lymphoblastic leukemia: results of CALGB 10403. Blood. 2019;133:1548-1559.

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