Improved outcomes after live donor renal transplantation for septuagenarians

Clin Transplant. 2020 Mar;34(3):e13808. doi: 10.1111/ctr.13808. Epub 2020 Feb 19.


The average age of renal transplant recipients in the United States has increased over the past decade. The implications, however, have not been fully investigated. We explored predictors of success and demographic variables related to outcomes in elderly live donor transplantation. Retrospective analysis was performed using the UNOS database between 2001 and 2016. Donor characteristics and the graft failure rate of recipients above and below 70 years of age were compared across four eras: 2001-2004, 2005-2008, 2009-2012, and 2013-2016. There was a steady increase in average donor age from the first era to the fourth era (40-44) which was more evident among the septuagenarian patients (43-50) (P < .001). The 2-year graft survival rate improved from 92% in the first era to 96% in the fourth era (P < .001), and this was also more prominent in the >70 population (87%-93%) (P < .001). The >70 recipients were more likely to be non-Hispanic white (80.1% vs 65.1%, P < .001) and male (70.1% vs 61.0% P < .001), respectively. The donors were more likely to be non-Hispanic white and female in the >70 population. Live donation in the elderly is justified based on graft survival and patient survival. However, racial and gender differences exist in septuagenarian recipients and their donors.

Keywords: elderly recipients; gender inequalities; kidney transplantation; live donation; live donor risks; racial inequalities; renal transplantation/nephrology; septuagenarian.

MeSH terms

  • Aged
  • Female
  • Graft Survival
  • Humans
  • Kidney Transplantation*
  • Living Donors*
  • Male
  • Registries
  • Retrospective Studies
  • Tissue Donors
  • United States / epidemiology