A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons

Nature. 1988 Dec 15;336(6200):638-46. doi: 10.1038/336638a0.


Thirty-five genes define a pathway for the development of the hermaphrodite-specific neurons (HSNs) in Caenorhabditis elegans. Some of these genes affect only one HSN trait, demonstrating that HSN migration, axonal outgrowth and serotonin expression are mutually independent events in HSN development; others, some of which are regulatory, affect multiple HSN traits. Nearly all are pleiotropic, revealing that the genes specifying HSN development also function in the development of other cell types.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Axons / physiology
  • Caenorhabditis / embryology*
  • Caenorhabditis / genetics
  • Disorders of Sex Development*
  • Genes*
  • Motor Neurons / physiology*
  • Mutation
  • Phenotype
  • Serotonin / physiology
  • Sex Factors


  • Serotonin