αIIb-Integrin (CD41) associated with blood eosinophils is a potential biomarker for disease activity in eosinophilic esophagitis

Mats W Johansson; Elizabeth M McKernan; Paul S Fichtinger; Evelyn L Angulo; Jennifer L Bagley; Kristine E Lee; Michael D Evans; Luis D Lomeli; Deane F Mosher; Shelly M Cook; Eric A Gaumnitz; Sameer K Mathur

doi:10.1016/j.jaci.2020.01.022

α_IIb-Integrin (CD41) associated with blood eosinophils is a potential biomarker for disease activity in eosinophilic esophagitis

J Allergy Clin Immunol. 2020 Jun;145(6):1699-1701. doi: 10.1016/j.jaci.2020.01.022. Epub 2020 Jan 28.

Affiliations

¹ Department of Biomolecular Chemistry, University of Wisconsin, Madison, Wis. Electronic address: mwjohansson@wisc.edu.
² Department of Medicine, University of Wisconsin, Madison, Wis.
³ Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, Wis.
⁴ Department of Biomolecular Chemistry, University of Wisconsin, Madison, Wis; Department of Medicine, University of Wisconsin, Madison, Wis.
⁵ Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wis.

Abstract

After EoE treatment, association of platelets with blood eosinophils, as reported by CD41, predicted esophageal eosinophil count. Percentage CD41+ circulating eosinophils is a potential non-invasive biomarker for EoE disease activity.

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Adult
Biomarkers / blood*
Eosinophilic Esophagitis / blood*
Eosinophilic Esophagitis / immunology*
Eosinophils / immunology*
Esophagus / immunology*
Female
Humans
Male
Platelet Membrane Glycoprotein IIb / immunology*

Substances

Biomarkers
Platelet Membrane Glycoprotein IIb